Susceptibility pattern of H.pylori after treatment failure

Abstract number: R2322

Rasmussen L., Alimoradi J., Boschian A., Andersen L.P.

Objectives: According to the Maastricht III Consensus, H. pylori test and treat is the strategy of choice in most H. pylori infected patients and PPI combined with amoxicillin and clarithromycin/metronidazole is recommendated as first line treatment. There is a growing concern regarding antibiotic resistance in H. pylori, which can result in treatment failure. The aim of this study was to evaluate the susceptibility pattern of H. pylori strains after treatment failure in Danish patients.

Methods: 50 clinically isolated H. pylori strains were susceptibility tested by E-test for amoxicillin, metronidazole, ciprofloxacin, levofloxacin, clindamycin, erythromycin, clarithromycin, rifampicin, tetracycline and meropenem.

The bacteria were grown and susceptibility tested according to the manufacturer.

Results: 74% of the strains were resistant to metronidazole, 54% were resistant to clindamycin and clarithromycin and 52% were resistant to erythromycin while 36% of the strains were resistant to all those 4 antibiotics at the same time. All strains were susceptible to amoxicillin, ciprofloxacin, levafloxacin, tetracycline and rifampicin.

Conclusion: This study shows a high rate of resistance to the most commonly used antibiotics and a high rate of multiresistant strains in patients with treatment failure. This suggests that antimicrobial susceptibility testing should be done after the first treatment failure.

Session Details

Date: 07/05/2011
Time: 00:00-00:00
Session name: Abstracts of 21st ECCMID / 27th ICC
Location: Milan, Italy, 7 - 10 May 2011
Presentation type:
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