Antibiofilm activities of bismuth-thiol-biocides on bacteria isolated from urinary catheter surfaces

Abstract number: P1860

Rahmany G., Abdi Ali A., Mohammadi P.

Objectives: The urinary catheters used in patients, can be colonized by the microorganisms which produce biofilm if they remain in their urinary tract for a long period. This structure acts as an accumulating center for infections; since prohibition of biofilm formation in the urinary catheter is essential. This study focus on inhibiting biofilm production on the catheter surfaces by use of bismuth ethanedithiol (BisEDT) and bismuth propanedithiol (BisPDT).

Methods: In this study we used Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter dissolvens, Staphylococcus aureus and Enterococcus faecalis which were isolated from Foley catheters previously. We determined MICs of each isolate in presence of BisEDT and BisPDT by microdilution technique and biofilm formation in presence of BTs was measured quantitatively by microtiter plate and crystal violet methods.

Result: MICs and biofilm inhibition percentage amounts of each bacterium in presence of biocides are shown in table 1. Results showed that BTs at MIC and sub-MIC concentrations inhibited biofilm production significantly (P < 0.05).

Conclusion: The unique antibiofilm properties of BTs may be useful to prevent or treat catheter associated urinary tract infections (CAUTI) due to bacteria that can attach and produce biofilm on catheter surfaces. It seems that coating catheters with BTs can inhibit biofilm formation on their surfaces significantly and prevent CAUTI in patients.

Session Details

Date: 07/05/2011
Time: 00:00-00:00
Session name: Abstracts of 21st ECCMID / 27th ICC
Location: Milan, Italy, 7 - 10 May 2011
Presentation type:
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