Antibiotic susceptibility pattern of nosocomial and community-acquired Clostridium difficile in Hungary

Abstract number: P1106

Terhes G., Sóki J., Latkóczy K., Szikra L., Konkoly-Thege M., Princz G., Nagy T., Osztie H., Urbán E.

Objectives: The rising incidence of C. difficile infection is getting more and more important, this has been partly attributed to the increased consumption of broad-spectrum antibiotics among hospitalized patients and in the community. The increased antibiotic consumption may have impact on the emergence of multiple resistant C. difficile strains too; therefore our aims were to continue our previous investigations, in which changes in the antibiotic susceptibility patterns of toxigenic C. difficile isolated from human diarrhoeal faeces were determined.

Methods: Up to this time, 171 toxigenic C. difficile strains isolated between 2008 and 2010 in three Hungarian laboratories represented West, East and South Hungary from diarrhoeal faecal samples of both inpatients and outpatients were analyzed. Antibiotic susceptibility of the isolated toxin-positive strains was determined by MIC Test Strip (Liofilchem, Italy) for metronidazole, moxifloxacin, clindamycin, erythromycin and rifampicin. The results were compared with our earlier findings given in 2007.

Results and Conclusion: All of the tested isolates were susceptible to metronidazole during the recent study period. 39 (22.8%) moxifloxacin resistant isolates were detected between 2008 and 2010. The prevalence of erythromycin resistant isolates was 28.7%, while 19.9% of tested strains proved to be resistant to clindamycin. 12.3% of the isolates were resistant to rifampicin. In comparison of the given results with our data from a previous study, in Hungary, all of the tested isolates were sensitive to metronidazole, the prevalence of isolates resistant to moxifloxacin, or erythromycin, or clindamycin has not been increased, while the prevalence of rifampicin resistant isolates was higher between 2008 and 2010.

This work was supported by ESCMID/bioMérieux grant 2010.

Session Details

Date: 07/05/2011
Time: 00:00-00:00
Session name: Abstracts of 21st ECCMID / 27th ICC
Location: Milan, Italy, 7 - 10 May 2011
Presentation type:
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